Harlem Heroes

Harlem Heroes was a strip from the early days of 2000AD; created by Pat Mills, Tom Tully and Dave Gibbons, it first appeared in 2000AD #1 in February 1977, and originally ran until #29 (with Massimo Belardinelli taking over from Gibbons as artist on the final three episodes) as well as the 1978 and 1979 editions of the 2000AD Annual.

The Story
Harlem Heroes is set after the year 2050, where a new sport, Aeroball, which combines elements of football, basketball and boxing, is sweeping the world. The jet pack wearing Heroes, led by John "Giant" Clay and including Slim, Hairy and Louis Meyer, are among the best Aeroball teams in the world, until a bus crash kills all of the team but these four...with Louis being left as a disembodied brain in a jar, capable of seeing and talking but nothing else! Louis nonetheless convinces his three surviving mates that they must rebuild the team and win the world championship, taking on new recruits such as Zack (and later on, Louis the Brain himself in a new android body) but things take a sinister turn when it slowly becomes apparent that the "accident" which killed the original team was nothing of the kind...

Follow-Up Stories
The surviving Heroes returned for a sequel series, Inferno (set in 2078), in 2000AD #36-75, while John "Giant" Clay...by now the only survivor...eventually reappeared as an old man, the father of Judge Giant, in a Judge Dredd strip set in 2099 (his eventual fate would be addressed by Gordon Rennie and Rufus Dayglo in the one-off story Whatever Happened to John "Giant" Clay? in Judge Dredd Megazine #216, set in 2126.

Second Series
A revived Harlem Heroes strip by Michael Fleisher and (for the majority of its run) Steve Dillon, featuring none of the original Heroes and a completely new premise (but reviving Clay's arch-foe, the psychotic cyborg Artie Gruber) and set in 2109, began several years later in 2000AD #671 and ran intermittently until #779, before returning for a final stretch in #928-939. Since the original series is pretty clearly set in the same timeline as Judge Dredd, however, and the second series appears not to be, it's entirely possible that despite Gruber's presence and references to the original team, this is actually set in an alternate timeline.